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Therapeutische Wirkung von Shumin Stern RF mit Hydroxychloroquin auf empfindliche Gesichtshaut kombiniert

12/25/2019

Objective: To investigate the clinical efficacy of ShuMin Star radiofrequency combined with hydroxychloroquine in the treatment of sensitive skin on the face.

Methods: 98 patients with facial sensitive skin were randomly divided into two groups. Both groups were given a topical moisturizer (ShuMin moisturizer) once in the morning and evening as the basic skin care treatment for the disease. Oral hydroxychloroquine sulfate tablets 0.22g, 2 mal / day in the phototherapy group; the radio frequency group combined with ShuMin Star radiofrequency moisturizer based on the oral hydroxychloroquine: once every 3 days in the 1st and 2nd week, and in the 3-4th week The week is once every week; the course of treatment is 4 Wochen, and the efficacy is judged on the 1st, 2nd and 4th week of treatment. Results The effective rates of the RF group in the first weekend, the second weekend, and the fourth weekend were 48.97%, 73.47%, und 89.80%, which were significantly higher than those in the phototherapy group (16.33%, 30.61%, und 38.76%, beziehungsweise). All were statistically significant (P <0.05).

CONCLUSION: On the basis of topical moisturizer skin care, ShuMin Star RF combined with hydroxychloroquine can significantly improve the clinical efficacy of sensitive skin on the face, which is better than hydroxychloroquine alone, and is worthy of clinical promotion.

Sensitive skin on the face is mostly caused by long-term external use of hormones, poor skin care methods, and loss of care after laser treatment. The sebum film and its “Ziegelwandstruktur” are damaged, the skin barrier function is reduced, and it is difficult to withstand external stimuli. A series of immune inflammatory reactions.

Clinical manifestations are repeated facial desquamation, erythematous pimples, Trockenheit, etc., accompanied by itching, Verbrennung, Dichtheit, cold and heat intolerance and other symptoms, often causing great pain to patients. The mechanism of its occurrence is complex, among which the impaired skin barrier function is one of the important causes; hydroxychloroquine has a good clinical effect in the treatment of sensitive skin on the face, but the current clinical observation cannot rely on the drug and external moisturizer to achieve rapid The effect of eliminating symptoms, repairing skin barrier and shortening the course of disease.

Because of its powerful moisturizing effect, ShuMin Star Radio Frequency Technology can effectively introduce humectants to promote the repair of sensitive skin. Deshalb, based on topical moisturizer skin care, this study used ShuMin Star Radio Frequency combined with hydroxychloroquine to treat sensitive skin with satisfactory results, which are reported as follows.

1. Materials and methods

1.1 Inclusion and exclusion criteria

Inclusion criteria

① Meet the diagnostic criteria for sensitive skin of the face: the patient has a long history of topical glucocorticoids, poor cosmetics or frequent inappropriate beauty; recurrent erythema, Pickel, dryness and desquamation on the face, and may be accompanied by thin epidermis, telangiectasia and other symptoms Patients consciously have stinging, Verbrennung, Dichtheit, and itching to varying degrees.

② Patients aged 18 zu 60 years are not limited to men and women.

③ willing to accept the treatment plan. This study was approved by the ethics committee of our hospital. All patients who signed up for the treatment signed theInformed Consent for ShuMin Star Treatment”.

Exclusion criteria

① Those who have seborrheic dermatitis and acne, etc..

② pregnant and lactating women;

③ Patients with severe heart, Niere, liver, endocrine and other systemic diseases or patients with tumors or immunodeficiency diseases;

④ The whole research period cannot be guaranteed without using other similar products, receiving other treatment methods (sowie: anti-allergic, glucocorticoids, immunosuppressive agents, etc.), and not eating spicy, sweet food and avoid alcohol;

⑤ Terminate treatment due to adverse reactions or other reasons.

1.2 Normal materials

98 patients met the inclusion criteria and were included in the treatment observation, von welchem 16 were male and 82 were female, von welchem 60 were caused by hormone-dependent dermatitis, 20 were caused by cosmetic dermatitis, 9 were caused by laser postoperative dermatitis, 9 For non-inductive sensitive skin. The age ranged from 18 zu 56 Jahre (mean, 34.84 ± 11.65) Jahre. The course of disease ranged from 2 months to 6 Jahre, with an average of 6.8 Monate. According to the order of consultation, 49 patients were randomly divided into the light therapy group and the radio frequency group. There was no significant difference in age, Geschlecht, disease duration, and severity of skin lesions between the two groups (P> 0.05), and they were comparable.

1.3 Treatment method

Both the phototherapy group and the radio frequency group were given a topical moisturizer (ShuMin moisturizer) morning and evening, as the basic skin care treatment for the disease. Oral hydroxychloroquine sulfate (brand name: Funle, Shanghai Zhongxi Pharmaceutical Co., Ltd.) 0.2G, 2 mal / day, in the phototherapy group; on the basis of the phototherapy group, ShuMin Star Radio Frequency Therapy Device was introduced to introduce ShuMin Moisturizer 30 mir, once every 3 days in the first and second weeks, once a week in the third and fourth weeks; a course of treatment lasts for 4 Wochen. Arbeitsschritte: According to the instructions of ShuMin Star Radio Frequency Therapy Device, clean the entire skin before treatment, and apply ShuMin moisturizer to the area to be treated, and gently press the treatment head on the area to be treated to ensure that it is vertically coupled with the skin. The treatment sequence is from bottom to top, following the direction of facial skin texture. Mineral water was dripped onto the face during the treatment. The main techniques are circle and gentle.

1.4 Efficacy criteria

Observe and record the changes before and after treatment, including whether there are side effects, subjective symptoms (Verbrennung, Juckreiz, und Dichtheit), objective signs (judgment by a person: skin flushing or redness, Pickel, Pusteln, Trockenheit, Schuppung, Pigmentation, skin atrophy, und Teleangiektasien, etc.) were scored on a 4-point scale of none, Licht, medium, and heavy, das ist, 0 points = none, 1 point = mild, 2 points = moderate, und 3 points = severe . Efficacy index = (points before treatment-points after treatment) / total points before treatment × 100%. The cure rate is ≥95%, the marked effect is 60% -94%, the improvement is 20% -59%, and the invalidity is <20%; the effective rate is calculated as cure plus marked effect. Hydroxychloroquine adverse reactions: Hematuria, liver and kidney function, and ophthalmological examinations were performed in patients in the phototherapy group and the treatment group before, 2 und 4 weeks after treatment.

1.5 Statistical processing

SPSS 13.0 software was used for statistics. The comparison of the effectiveness was performed by χ2 test. P <0.05 was considered statistically significant.

2. Results

2.1 Clinical efficacy

The overall clinical treatment effect of the two groups of patients is shown in Table 1. Nach 1 week of treatment, the effective rate in the radio frequency group was higher than that in the phototherapy group. The difference between the two groups was statistically significant (48.97% vs 16.33%, χ2 = 4.61, P <0.05, see Table 1). Nach 2 wöchiger Behandlung, the radio frequency group had a higher effective rate than the phototherapy group, and the difference between the two groups was statistically significant (73.47% vs 30.61% χ2 = 3.81, P <0.05, see Table 2); nach 4 wöchiger Behandlung, the radio frequency group and the phototherapy group The effective rates were 89.80% und 38.76%, beziehungsweise. The difference between the two groups was statistically significant (χ2 = 4.16, P <0.05, see Table 3). The RF group achieved good results in treating sensitive skin.

The overall clinical treatment effect of the two groups of patients is shown in Table 1. Nach 1 week of treatment, the effective rate in the radio frequency group was higher than that in the phototherapy group. The difference between the two groups was statistically significant (48.97% vs 16.33%, χ2 = 4.61, P <0.05, see Table 1). Nach 2 wöchiger Behandlung, the radio frequency group had a higher effective rate than the phototherapy group, and the difference between the two groups was statistically significant (73.47% vs 30.61% χ2 = 3.81, P <0.05, see Table 2); nach 4 wöchiger Behandlung, the radio frequency group and the phototherapy group The effective rates were 89.80% und 38.76%, beziehungsweise. The difference between the two groups was statistically significant (χ2 = 4.16, P <0.05, see Table 3). The RF group achieved good results in treating sensitive skin.

During the treatment of the two groups, no serious adverse reactions occurred. In the radio frequency group, 3 cases of discomfort occurred during the treatment: Juckreiz, Verbrennung, and improvement after icing. After the next treatment, no discomfort was seen. Twelve patients in the light therapy group had obvious dryness, Schmerzen, and tightness at 2 Wochen. The number and dosage of topical ShuMin moisturizers were increased, and symptoms improved. Adverse reactions to hydroxychloroquine: 3 of the 49 patients in the phototherapy group and 1 of the 49 patients in the treatment group experienced mild nausea and abdominal discomfort, which occurred 1 zu 2 weeks after treatment. The treatment did not stop and the symptoms resolved on their own. No abnormalities in hematuria and liver and kidney function were detected before, 2 und 6 weeks after treatment in the light therapy group and the treatment group. No fundus examination was found in the light therapy group and the treatment group before, 2 und 4 weeks after treatment.

3. Discussion

Sensitive facial skin manifests as diffuse erythema, Schuppung, Ödem, acne-like rash, etc., accompanied by obvious itching and burning sensations, which eventually lead to capillary dilation, skin atrophy, Pigmentierung, etc., which seriously affects the physical and mental health of patients. Gegenwärtig, its pathogenesis is not completely clear. It may be mainly related to the impaired skin barrier function, vascular and nerve hyperresponsiveness and microbial infection. Deshalb, the author believes that effective treatment and shortening of the disease course can greatly relieve the physical and mental suffering of patients, and it is necessary to adopt comprehensive treatment. The main treatment links are as follows:

① find out the cause, if it is a long-term topical hormone, uncomfortable skin care products, immediately discontinue and use safe withdrawal alternative treatment to give psychological counseling;

②The second is to eliminate the inflammatory response, and drugs such as hydroxychloroquine and relapsed glycyrrhizin can be given;

③ Promote the repair of damaged skin barrier function, and can give ShuMin moisturizing repair agent and other medical skin care products. In order to promote skin barrier repair, in this study, both the phototherapy group and the radiofrequency group were given a topical ShuMin moisturizer as a basic treatment for moisturizing skin care.

On this basis, this study shows that hydroxychloroquine has a good effect in treating sensitive skin of the face, and the effective rate gradually increases with the treatment time. Nach 1 Woche, 2 Wochen, und 4 wöchiger Behandlung, the effective rates are 16.33% und 30.61%, beziehungsweise. 38.76%. Hydroxychloroquine is currently the basic drug for the clinical treatment of systemic lupus erythematosus, and it is also the first choice for dermatology to treat sensitive skin on the face.

Studies have found that hydroxychloroquine has reduced skin sensitivity to ultraviolet light, stabilized lysosomal membranes, inhibited the binding of denatured DNA to antibodies, inhibited cellular immunity and complement activity, and also found that chlorochloroquine could inhibit CD4 + Foxp3 + Treg cell proliferation in vitro And differentiation, it is speculated that this mechanism may also play a role in inhibiting the inflammatory response of sensitive skin on the face.

The principle of ShuMin Star is mainly through radio frequency electric field therapy and computer and electronic technology. Using insulated electrodes near the skin surface, the energy is transferred to the subcutaneous tissue by means of radio frequency electric field introduction. Radio frequency electric field therapy uses ionization and penetration to electrolyze water molecules on the surface of the skin into an ionic state. Due to the repulsion of homopolar ions, the electrolyzed ions can be quickly introduced into the basal layer of the skin through the ion channels between the cells to replenish the skin with moisture. Radio frequency energy stimulates the repair of skin keratinocyte function, reconstructs the skin brick structure, and repairs the skin barrier function. The oxygen released during the treatment promotes skin blood circulation and metabolism and absorption of inflammatory factors, thereby achieving the purpose of anti-inflammatory and sterilization.

Deshalb, it is precisely the use of ShuMin Star’s super-permeability. in dieser Studie, ShuMin Star Instrument was used to introduce medical skin care products (ShuMin moisturizer) with good moisturizing properties into damaged skin. Observe this technology to treat sensitive skin on the face. Efficacy. The results of this study showed that the effective rates (18.9, 73.47%, und 89.80%, beziehungsweise) of the RF group after the first week, 2 Wochen, und 4 weeks were significantly higher than those of the phototherapy group (16.33%, 30.61%, und 38.76%) The differences were statistically significant (P <0.05). It can be seen that on the basis of external moisturizing skin care agents to repair the skin barrier, the clinical efficacy of ShuMin Star Radio Frequency Technology combined with hydroxychloroquine is significantly better than that of hydroxychloroquine alone. We found in the study that most patients were relieved of skin irritation such as dry skin, prickelnd, hot skin, Spülung, and tightness immediately after treatment; gleichzeitig, the non-invasiveness, comfort and immediate effect of the technology Sex, very well recognized by patients with sensitive skin.

The reason why this technology is superior to hydroxychloroquine alone may be related to the super ionization principle of ShuMin Star, which exerts a strong penetration effect, so that ShuMin moisturizer can effectively penetrate into the basal layer of the skin quickly, thereby exerting immediate anti-inflammatory , Hydrating, repair damaged skin barrier effect. The ShuMin Star radio frequency technology used in this study was accepted by the majority of patients. This technology is worthy of clinical promotion.

4. Fazit

ShuMin Star is a brand new patented sensitive skin repair and treatment product developed by our company based on the skin characteristics of Chinese people. Nach Tausenden von klinischen Zertifizierungen, ShuMin Star is repairing skin barrier function, stimulating skin collagen regeneration and restoring skin health Directly address the roots of sensitive skin, and fill the gaps in the treatment of sensitive skin in China in a timely manner. It will bring a more professional quality medical skin care journey for all patients with skin problems, and start a new era of sensitive skin repair!

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