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308 nm Excimer-Laser ist für Vitiligo und Scleroderma

05/08/2019

1.Introduction of 308 nm excimer laser machine

Der Mechanismus der UV-Licht bei der Behandlung von Vitiligo kann auf die Apoptose von T-Zellen zusammenhängen. Immunhistochemie zeigte, daß das 308-nm-UV-Licht konnte die infiltrierenden T-Lymphozyten in der Haut lesions.It klar wurde gefunden, dass UV-Licht bei 308 nm konnte die Apoptose von aktivierten T-Zellen in Vitiligo lesions.After Bestrahlung fördern, T-Zellen können die Apoptose unterziehen, so dass die Hautveränderungen nicht nur vollständig auf dem bloßen Augenhöhe verschwinden, aber auch zurück in der normalen Gewebestruktur auf der mikroskopischen level.Vitiligo wird durch selektive Zerstörung Melanozyten gekennzeichnet und kann mit einem Autoimmun response.Ultraviolet Licht mit einer Wellenlänge von 308 nm in Schmalspektrum-UV-B verbunden sein kann, eine immunmodulatorische Rolle in der Zelle und humorale Immunität spielen, die den Prozess der depigmentation.Recent Studien stabilisieren haben gezeigt, dass verschiedene Cytokine und Entzündungsmediatoren erhöhen nach Exposition gegenüber UVB, was darauf hindeutet, dass dies ein Mechanismus ist, durch den bei UVB Pigment recovery.Ultraviolet Licht induziert 365 nm 6 nm haben die Funktion, die zelluläre Immunität zu steigern, die die vorzeitige Apoptose von Zellen durch ultraviolettes B-Segment verursacht simulieren, die Regeneration von metabolischen Epithels verbessern und töten Bakterien, vor allem bei Hautläsionen gezielt.

2.Hauptanwendung 308 nm excimer laser machine

Durch die Entdeckung der therapeutischen Wirkung von 308 nm-Excimer-Laser auf Hautkrankheiten, Die FDA begann sie bei der Behandlung von Hautkrankheiten zu verwenden, in 2000. Im 2005, it was certified by the state food and drug administration (CFDA) and entered China.The 308nm excimer laser therapeutic instrument is a device for clinical medicine to generate excimer laser.308nm excimer laser is mainly used in clinical treatment of vitiligo, Psoriasis, dermatitis and chronic eczema.

The skin treatment effect of 308nm excimer laser is as follows:

1) Melanozyten Proliferation stimulieren und Melanozyten-Produktion fördern.

2) inducing T cell death.

3) promote the production of vitamin D3.

4) activation of pseudocatalase.

 

3.Features of 308 nm excimer laser machine

1) research results of wuhan institute of physics and mathematics, Chinese academy of sciences.

2) the world’s only semiconductor crystal (solid) laser anti-vitiligo equipment.

3) the enemy of vitiligo, Psoriasis.

4) the world’s first UVB+UVA1 combined therapy platform.

 

4.Principle of 308 nm excimer laser machine

The etiology and pathogenesis of vitiligo are still unclear, and there are many hypotheses to explain various clinical manifestations.The mechanism of 308 nm excimer laser in the treatment of vitiligo may be related to the apoptosis of T cells.Bianchi et al. showed that 308 nm excimer laser can remove infiltrated T lymphocytes in the skin lesions by immunohistochemical method.Novak et al. festgestellt, dass 308 nm excimer laser can promote apoptosis of activated T cells in vitiligo lesions.Its effect is more obvious than the ability of narrow wave ultraviolet ray to induce apoptosis.After irradiation, T-Zellen können die Apoptose unterziehen, so dass die Hautveränderungen nicht nur vollständig auf dem bloßen Augenhöhe verschwinden, but also return to normal tissue structure at the microscopic level.Vitiligo is characterized by selective melanocyte destruction and may be associated with an autoimmune response.Narrow-spectrum uvb (NB2UVB) may play an immunomodulatory role in cell and humoral immunity, which can stabilize the process of depigmentation.In addition, narrow-spectrum uvb is also widely recognized to have similar efficacy to PUVA (psoralen photochemotherapy) in stimulating residual melanocytes to accumulate in the outer root sheath of the peripheral hair follicle.Melanocyte mitosis, melanogenesis and its migration are often induced by a variety of cytokines and inflammatory mediators, including interleukin 1, TNF, and leucone-c4.Recent studies have shown that various cytokines and inflammatory mediators increase after exposure to UVB, suggesting that this is a mechanism by which UVB induces pigment recovery.

 

5.Advantages of 308 nm excimer laser machine

1) green safety: Nicht-toxische Nebenwirkungen, no drug dependence, has been approved by China CFDA certification, patients can rest assured to choose.

2) safe without damage: for the cause, direct to the lesion, without any damage to healthy skin.

3) stable band, rapid effect, short treatment time: it is a pulsed light wave treatment technology, through a single band of 308nm excimer laser, the energy is effectively focused on the lesion, targeted treatment, effective rapid treatment time than traditional instruments shortened 3-5 mal.

4) hohe Heilungsrate: the cure rate of 308nm excimer laser skin treatment system is over 90%.

5) keine besonderen Einschränkungen Website: für alle Arten von weißen Flecken, verschiedene Teile des Körpers,, Kopf und Gesicht, Schleimhaut, Genital kann treated.And kann die Stelle von anderen Bereich wählen Behandlung haben nach verschiedenen Behandlungsbereich, vermeiden normale Haut zu verletzen effektiv.

6) bevorzugte Behandlung für Vitiligo bei schwangeren Frauen und Kindern: für alle Gruppen geeignet, jedes Alter, ist nicht geeignet für Medikamente langfristige, nicht geeignet für die Melanin Anbau, für Schwangere, Kleinkinder, schwache Verfassung, Xenon 308 chloride laser technology is the preferred treatment for vitiligo.

7) the early treatment effect is obvious, effectively prevent recurrence: 308 laser technology special light waves, on the one hand can rapidly induce T cell apoptosis, on the other hand can make the melanin fully activated, severely, fundamentally thoroughly solve the problem of melanin cells are destroyed, effectively prevent recurrence, has an obvious effect of early treatment of vitiligo.

8) follow treatment at any time without delaying study and work: receiving 308 laser treatment without preparation before irradiation, the formal irradiation time is short, follow treatment at any time without affecting the work and study of patients.

 

6.Treatment differences of 308 nm excimer laser machine

There are individual differences of excimer laser in the treatment of vitiligo.It is related to the following factors: skin color (skin type), skin lesion time (generally short onset time and rapid recovery), skin lesion site (the best treatment effect of head and facial trunk, followed by limbs, poor treatment of palm and plantar on the dorsum of fingers and more times than that of head and facial).

Excimer laser in the treatment of psoriasis, individual differences are not significant, but there are also small differences in skin lesions (head and face trunk than limbs).

What are the reasons for the difference in therapeutic effect between different body parts?

Die direkten Gründe für die Bildung von ungewöhnlicher Art von Vitiligo sind weißen Fleck Melanozyten wegen T-Lymphozyten-Immun Tötung durch Tod von T-Lymphozyten in Immunschäden, wenn brauchen die Sicherheit des Ziels zu identifizieren “Identität”, wodurch die Vitiligo T-Zell-Spezifität Erkennung und Zerstörung von Melanocyten, der menschliche Haarfollikel Melanozyten existiert in einem Zustand der Natur in sie die Eigenschaften von Melanozyten-Tags nicht exprimieren, so kann in der Regel die Killer-T-Zellen entkommen, the recovery of vitiligo need excimer laser stimulation of these remaining in the original state of melanocyte growth as a function of mature melanocyte and bringing back vitiligo skin,This is the reason why when vitiligo is recovered, the pigment islets often appear around the sweat pores first, and then the islets expand and finally recover. The difference in the response of different parts of the body to treatment is related to the distribution density of hair follicles in different parts of the body, the type of hair follicles, and the blood supply to the skin.There is no follicular structure in the palm and plantar so treatment is most difficult.

 

7.Security of 308 nm excimer laser machine

1) is the excimer laser treatment system safe and can it damage the skin?

Excimer laser treatment of skin diseases is very safe, it has been approved by China’s CFDA, and there has been no adverse reactions reported, not to mention the risk of cancer.Its square spot can avoid laser irradiation of normal tissue, minimizing damage to normal skin.

2) is there any possibility of adverse reactions?

während der Behandlung, there is only a slight burning sensation at the irradiated site, and some patients may feel a slight pain (similar to mild sunburn) at the site several hours after treatment.For patients with psoriasis may appear some erythema, or a short period of postoperative pigmentation (recoverable).In patients with vitiligo, there is almost no side effect, occasionally resulting in slight blisters due to increased energy.

3) can excimer laser cause skin cancer?

Traditional phototherapy, especially UVA (PUVA) or UVB, has been reported to cause skin cancer.The 308 excimer laser from the study has not been reported to induce skin cancer.

4) in addition to vitiligo and psoriasis, molecular laser treatment system can also treat those diseases?

Excimer laser is licensed for the treatment of vitiligo and psoriasis.More and more extensive applications have been verified by the clinical practice of domestic and foreign doctors, including various diseases of pigment loss, such as atrophic scar, stretch marks, palmoplantar impetigo, Alopecia areata, infant eczema, neurodermatitis and other refractory skin diseases.

5) can it be used for babies?

Excimer lasers can be used safely in people of all ages, from infants to the elderly.

6) what is the difference between the 308 excimer laser and the excimer laser used to treat myopia?

There are many kinds of excimer laser, such as ArF(193nm), KrCl(233nm), KrF(248nm), XeCl(308nm), XeF(353nm), etc.. Ophthalmology generally USES ArF at 193nm and KrF at 248nm. Different excimer laser selection is selected by laser characteristics and therapeutic purposes.

 

8.Intended population of 308 nm excimer laser machine

The effect of laser therapy varies with location and age of onset.The best suitable population for 308nm therapeutic instrument:

1) better curative effect on face, neck and trunk and limbs;

2) patients with vitiligo who are less than 18 years old and have a weak constitution have better efficacy;

3) the light beam has no harm to pregnant women, so ist es für Schwangere geeignet;

4) Xtrac excimer laser treatment system is effective for advanced vitiligo.

Applicable patients:

1) patients with initial vitiligo

2) patients with vitiligo acromelitigo, segmentary type, normal type, hair follicle type, and localized type

3) patients with persistent vitiligo

4) patients with recurrent relapse after treatment of vitiligo

5) children with vitiligo, etc.

 

9.Contraindication of 308 nm excimer laser machine

If the patient has the following symptoms, it is forbidden to use the excimer laser treatment system:

1) patients with photoallergy

2) patients with keloid or a history of keloid formation

3) patients with birthmark tumor or a history of the formation of the tumor

4) patients with diffuse squamous cell carcinoma.

 

10.Advances in laser therapy of 308 nm excimer laser machine

Vitiligo is a common skin disease, and the current treatment methods are various, including systemic and local hormone therapy, immunomodulator therapy, surgical treatment and traditional Chinese medicine treatment, among which light therapy is one of the most effective treatment methods.In 1975, PUVA(psoralen photochemotherapy) was used to treat skin diseases such as psoriasis and vitiligo.In 1981, Parrish and Jaenicke experiment found that UVB(medium-wave ultraviolet) with a wavelength between 300 und 313 nm was the most effective in the treatment of psoriasis. Based on this theory, narrow spectrum UVB(NB2UVB, 311 nm) therapy for psoriasis obtained more superior efficacy than traditional therapy.In 2001, zhengzhou huaxia hospital of vitiligo and many other scientific research institutions applied 308 nm excimer laser to the clinical treatment of a 24-year-old female patient with vitiligo. The results showed that the treatment effect of 308 nm excimer laser was more accurate.

Vitiligo experts clearly pointed out that: the 308-nm excimer laser is highly effective, safe and can selectively act on lesions and lesions, making it the best choice for vitiligo phototherapy.

 

11.Summarize of 308 nm excimer laser machine

The high energy, high density, Targeting, accuracy and compliance of our 308nm treatment instrument can significantly improve the treatment effect of vitiligo and scleroderma.

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